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List of substances for condition Group: Fibrosis

All Human Animal Risk/Association ReviewRows: 333

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Curcumin 📋✍⛔38669311The Potential Mechanism of the Anti-Liver Fibrotic Effect of Curcumin in the Gut-Liver Axis
Astragalosides 📋✍⛔38718959Integrative transcriptomics and proteomics analysis reveal the protection of Astragaloside IV against myocardial fibrosis by regulating senescence
Resveratrol 📋✍⛔38618058Resveratrol inhibits arecoline-induced fibrotic properties of buccal mucosal fibroblasts via miR-200a activation
Ginsenosides 📋✍⛔38683298Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy
Melatonin 📋✍⛔38688425Melatonin prevents pulmonary fibrosis caused by PM2.5 exposure by targeting epithelial-mesenchymal transition
Vitamin D3 📋✍⛔38413933Effects of vitamin D supplementation on liver fibrogenic factors, vitamin D receptor and liver fibrogenic microRNAs in metabolic dysfunction-associated steatotic liver disease (MASLD) patients: an exploratory randomized clinical trial
Astragalus Root 📋✍⛔38584671Ferroptosis Mediates Pulmonary Fibrosis: Implications for the Effect of Astragalus and Panax notoginseng Decoction
EGCG 📋✍⛔38146662Epigallocatechin-3-gallate attenuates arsenic-induced fibrogenic changes in human kidney epithelial cells through reversal of epigenetic aberrations and antioxidant activities
Salvianolic Acid 📋 38662612SALVIANOLIC ACID A ATTENUATES ANGIOTENSIN II-INDUCED CARDIAC FIBROSIS THROUGH REGULATING THE TXNIP SIGNALING PATHWAY
Astaxanthin 📋✍⛔38524025Efficacy and Safety of Astaxanthin in the Management of Oral Submucous Fibrosis: A Preliminary Randomized Controlled Trial
Ginseng 📋✍⛔38632037Panax notoginseng saponins improve oral submucous fibrosis by inhabiting the Wnt/β-catenin signal pathway
Metformin 📋✍⛔38288020Metformin exerts anti-liver fibrosis effect based on the regulation of gut microbiota homeostasis and multi-target synergy
Quercetin 📋✍⛔38153514Quercetin influences intestinal dysbacteriosis and delays alveolar epithelial cell senescence by regulating PTEN/PI3K/AKT signaling in pulmonary fibrosis
Berberine 📋✍⛔38716621The Application of Berberine in Fibrosis and the Related Diseases
N-Acetyl Cysteine 📋✍⛔36873280N-Acetylcysteine attenuated pulmonary fibrosis induced by bleomycin via immunomodulation responses
Puerarin 📋✍⛔37556718Puerarin alleviated oxidative stress and ferroptosis during renal fibrosis induced by ischemia/reperfusion injury via TLR4/Nox4 pathway in rats
Genistein 📋✍⛔37817434Genistein alleviates pulmonary fibrosis by inactivating lung fibroblasts
Fucoidan 📋✍⛔37481747Fucoidan from Saccharina japonica Alleviates Hyperuricemia-Induced Renal Fibrosis through Inhibiting the JAK2/STAT3 Signaling Pathway
Vitamin C 📋✍⛔36145092α-Tocopherol Pharmacokinetics in Adults with Cystic Fibrosis: Benefits of Supplemental Vitamin C Administration
Angelica 📋✍⛔38490157Therapeutic potential of Angelica sinensis in addressing organ fibrosis: A comprehensive review
Baicalin 📋✍⛔37922789Baicalin ameliorates renal fibrosis by upregulating CPT1α-mediated fatty acid oxidation in diabetic kidney disease
Pterostilbene 📋✍⛔38429613Pterostilbene: a potential therapeutic agent for fibrotic diseases
Tanshinone 📋 38697470Tanshinone IIA alleviates pulmonary fibrosis by modulating glutamine metabolic reprogramming based on [U-13C5]-glutamine metabolic flux analysis
Asiatic Acid 📋 35963324Asiatic acid alleviates liver fibrosis via multiple signaling pathways based on integrated network pharmacology and lipidomics
Emodin 📋 ⛔38507311Emodin ameliorates myocardial fibrosis in mice by inactivating the ROS/PI3K/Akt/mTOR axis
Modified Citrus Pectin 📋✍⛔32172066Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4/MyD88/NF-κB signaling pathway
Schisandrins 📋 38382281Schisandrin A alleviates renal fibrosis by inhibiting PKCβ and oxidative stress
Silymarin 📋✍⛔38637422Silymarin and MSC-exosomes ameliorate thioacetamide-evoked renal fibrosis by inhibiting TGF-β/SMAD pathway in rats
Red Sage 📋✍⛔38237513Salvia miltiorrhiza Bunge extract and Przewalskin ameliorate Bleomycin-induced pulmonary fibrosis by inhibition of apoptosis, oxidative stress and collagen deposition via the TGF-β1 pathway
Schisandra 📋✍⛔37010139Schisandrin B promotes senescence of activated hepatic stellate cell via NCOA4-mediated ferritinophagy
TUDCA 📋✍⛔35607370Tauroursodeoxycholic acid inhibits TGF-β1-induced renal fibrosis markers in cultured renal mesangial cells by regulating endoplasmic reticulum stress
Vitamin E 📋✍⛔38125893Vitamin E stabilizes iron and mitochondrial metabolism in pulmonary fibrosis
Docosahexaenoic Acid 📋✍⛔38613004Impact of 1-Year Supplementation with High-Rich Docosahexaenoic Acid (DHA) on Clinical Variables and Inflammatory Biomarkers in Pediatric Cystic Fibrosis: A Randomized Double-Blind Controlled Trial
Fisetin 📋✍⛔37696989Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis
Ginkgo Biloba 📋✍⛔37971580Ginkgo biloba Extract 50 (GBE50) Exerts Antifibrotic and Antioxidant Effects on Pulmonary Fibrosis in Mice by Regulating Nrf2 and TGF-β1/Smad Pathways
Grape Seed extract 📋✍⛔36246170Bleomycin-Induced Damage in Rat Lung: Protective Effect of Grape Seed and Skin Extract
Lycopene 📋✍⛔38037248LYC inhibits the AKT signaling pathway to activate autophagy and ameliorate TGFB-induced renal fibrosis
Naringenin 📋✍⛔38576562Naringenin alleviates liver fibrosis by triggering autophagy-dependent ferroptosis in hepatic stellate cells
Omega-3 Fatty Acids 📋✍⛔37760994Omega-3 Fatty Acids Attenuate Renal Fibrosis via AMPK-Mediated Autophagy Flux Activation
Selenium 📋✍⛔36079882Inverse Association between Serum Selenium Level and Severity of Liver Fibrosis: A Cross-Sectional Study
Aloe Vera 📋✍⛔37694023Assessment of Aloe Vera and Tulsi's Effectiveness in Treating Oral Submucous Fibrosis
Amygdalin 📋✍⛔37944128Amygdalin and exercise training exert a synergistic effect in improving cardiac performance and ameliorating cardiac inflammation and fibrosis in a rat model of myocardial infarction
Apigenin 📋✍⛔37707699Idiopathic pulmonary fibrosis (IPF): disease pathophysiology, targets, and potential therapeutic interventions
Arctigenin 📋 38679116Arctigenin induces activated HSCs quiescence via AMPK-PPARγ pathway to ameliorate liver fibrosis in mice
Calycosin 📋 38726105Calycosin prevents NLRP3-induced gut fibrosis by regulating IL-33/ST2 axis
Chrysin 📋✍⛔35177130Evidence based mechanistic role of Chrysin towards protection of cardiac hypertrophy & fibrosis in rats
Ferulic Acid 📋✍⛔34566665Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation
Fucoxanthin 📋✍⛔38204245Fucoxanthin Enhances the Antifibrotic Potential of Placenta-derived Mesenchymal Stem Cells in a CCl4-induced Mouse Model of Liver Fibrosis
Honokiol 📋 37253375Honokiol inhibits epithelial-mesenchymal transition and hepatic fibrosis via activation of Ecadherin/GSK3β/JNK and inhibition of AKT/ERK/p38/β-catenin/TMPRSS4 signaling axis
Lipoic Acid 📋✍⛔34746462Modulation of COX-2 and NADPH oxidase-4 by alpha-lipoic acid ameliorates busulfan-induced pulmonary injury in rats
Mangiferin 📋 ⛔38225395Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis
Baicalein 📋✍⛔38601597Baicalein improves renal interstitial fibrosis by inhibiting the ferroptosis in vivo and in vitro
Coffee 📋✍⛔35514789Severe liver fibrosis in the HCV cure era: Major effects of social vulnerability, diabetes, and unhealthy behaviors
Dihydroartemisinin 📋 38463857Dihydroartemisinin (DHA) inhibits myofibroblast differentiation through inducing ferroptosis mediated by ferritinophagy
Ellagic Acid 📋✍⛔38406569Ellagic acid ameliorates renal fibrogenesis by blocking epithelial-to-mesenchymal transition
Icariin 📋✍ 35667261Endocannabinoid signalling/cannabinoid receptor 2 is involved in icariin-mediated protective effects against bleomycin-induced pulmonary fibrosis
Naringin 📋✍⛔37930368Naringin ameliorates liver fibrosis in zebrafish by modulating IDO1-mediated lipid metabolism and inflammatory infiltration
Nigella Sativa 📋✍⛔38051691The effectiveness of organic vegetable oils with high biocompatibility in preventing epidural fibrosis: An experimental study
Salidroside 📋 37544102Integrating network pharmacology and experimental verification to explore the mechanisms of salidroside against myocardial fibrosis
Taurine 📋✍⛔38681990Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis
Andrographolide 📋 34268377Andrographolide alleviates bleomycin-induced NLRP3 inflammasome activation and epithelial-mesenchymal transition in lung epithelial cells by suppressing AKT/mTOR signaling pathway
Asiaticoside 📋 36906159TMT quantitative proteomics and network pharmacology reveal the mechanism by which asiaticoside regulates the JAK2/STAT3 signaling pathway to inhibit peritoneal fibrosis
Cordyceps 📋✍⛔38375041Chemical components in cultivated Cordyceps sinensis and their effects on fibrosis
Crocin 📋✍⛔33295246Crocin inhibits the activation of mouse hepatic stellate cells via the lnc-LFAR1/MTF-1/GDNF pathway
Dihydromyricetin 📋✍⛔35359847Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway
Glycyrrhizic Acid 📋✍⛔36805480Glycyrrhizic acid alleviates liver fibrosis in vitro and in vivo via activating CUGBP1-mediated IFN-γ/STAT1/Smad7 pathway
Hesperidin 📋✍⛔37272929The renoprotective effects of hesperidin on kidney injury induced by exposure to severe chronic dust storm particulate matter through inhibiting the Smads/TGF-β1 signaling in rat
Luteolin 📋✍⛔37360572Luteolin Alleviates Liver Fibrosis in Rat Hepatic Stellate Cell HSC-T6: A Proteomic Analysis
Magnesium 📋✍⛔37770630Magnesium inhibits peritoneal calcification as a late-stage characteristic of encapsulating peritoneal sclerosis
Mangosteen 📋✍⛔38034260Inhibition of Oral Fibrinogenesis Through Transforming Growth Factor-Beta/SMAD2/3 Signalling Inhibition Using Mangosteen Pericarp Extract
Piperine 📋✍⛔34778375The Hepatoprotective Effect of Piperine Against Thioacetamide-Induced Liver Fibrosis in Mice: The Involvement of miR-17 and TGF-β/Smads Pathways
Zinc 📋✍⛔34739677Zinc Deficiency Aggravates Oxidative Stress Leading to Inflammation and Fibrosis in Lung of Mice
Anthocyanins 📋✍⛔38290991Blueberry anthocyanins improve liver fibrosis by regulating NCOA4 ubiquitination through TRIM7 to affect ferroptosis of hepatic stellate cells
Bee Propolis 📋✍⛔33613057Induction of liver fibrosis by CCl4 mediates pathological alterations in the spleen and lymph nodes: The potential therapeutic role of propolis
Capsaicin 📋✍⛔38449809Capsaicin ameliorate pulmonary fibrosis via antioxidant Nrf-2/ PPAR- γ pathway activation and inflammatory TGF-β1/ NF-κB/COX II pathway inhibition
Carvacrol 📋✍⛔36156620Carvacrol preserves antioxidant status and attenuates kidney fibrosis via modulation of TGF-β1/Smad signaling and inflammation
CoQ10 📋✍⛔35636077Coenzyme Q10 attenuates renal fibrosis by inhibiting RIP1-RIP3-MLKL-mediated necroinflammation via Wnt3α/β-catenin/GSK-3β signaling in unilateral ureteral obstruction
Dihydroquercetin 📋 35645837Dihydroquercetin Attenuates Silica-Induced Pulmonary Fibrosis by Inhibiting Ferroptosis Signaling Pathway
Diosmin 📋✍⛔38195573Diosmin ameliorates renal fibrosis through inhibition of inflammation by regulating SIRT3-mediated NF-κB p65 nuclear translocation
Gallic Acid 📋 ⛔32933341Attenuation of Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats by Combination Treatment of Two Natural Phenolic Compounds: Quercetin and Gallic Acid
Gotu Kola 📋✍⛔34350247Potential therapeutic targets and biological mechanisms of Centella asiatica on hepatic fibrosis: a study of network pharmacology
Kaempferol 📋✍⛔37820466Kaempferol attenuates carbon tetrachloride (CCl4)-induced hepatic fibrosis by promoting ASIC1a degradation and suppression of the ASIC1a-mediated ERS
L-Arginine 📋✍⛔38493696L-arginine mitigates bleomycin-induced pulmonary fibrosis in rats through regulation of HO-1/PPAR-γ/β-catenin axis
L-Carnitine 📋✍⛔34901512L-carnitine ameliorates bile duct ligation induced liver fibrosis via reducing the nitrosative stress in experimental animals: preclinical evidences
NMN 📋✍⛔36777361Nicotinamide mononucleotide attenuates HIF-1α activation and fibrosis in hypoxic adipose tissue via NAD+/SIRT1 axis
Paeoniflorin 📋 38489890Paeoniflorin promotes PPARγ expression to suppress HSCs activation by inhibiting EZH2-mediated histone H3K27 trimethylation
Reishi Mushrooms 📋✍⛔36703748Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis
Sulforaphane 📋✍⛔33388347Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway
Vitamin A 📋✍⛔37058112Low vitamin A levels are associated with liver-related mortality: a nationally representative cohort study
Aged Garlic 📋✍⛔29887949S-allyl-cysteine attenuates carbon tetrachloride-induced liver fibrosis in rats by targeting STAT3/SMAD3 pathway
Blueberry 📋✍⛔35418869Blueberry Juice Attenuates Pulmonary Fibrosis via Blocking the TGF-β1/Smad Signaling Pathway
Carnosic Acid 📋 32855722Carnosic acid protects against pressure overload-induced cardiac remodelling by inhibiting the AKT/GSK3β/NOX4 signalling pathway
Chlorogenic Acid 📋✍⛔38356488Chlorogenic Acid Inhibits Progressive Pulmonary Fibrosis in a Diabetic Rat Model
Geniposide 📋 37494875Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1/FXR signaling in bile duct ligation-induced liver fibrosis
Gingerol 📋✍ 352575536-Gingerol, a functional polyphenol of ginger, reduces pulmonary fibrosis by activating Sirtuin1
Hesperetin 📋 37697354Hesperetin attenuates the expression of markers of adipose tissue fibrosis in pre-adipocytes
Nicotinamide Riboside 📋✍⛔35643283Nicotinamide riboside supplementation exerts an anti-obesity effect and prevents inflammation and fibrosis in white adipose tissue of female diet-induced obesity mice
Rosmarinic Acid 📋✍ 38397744Therapeutic Potential and Mechanisms of Rosmarinic Acid and the Extracts of Lamiaceae Plants for the Treatment of Fibrosis of Various Organs
Rutin 📋✍⛔38006284Investigating rutin as a potential transforming growth factor-β type I receptor antagonist for the inhibition of bleomycin-induced lung fibrosis
Sesamol 📋 37976698Sesamol as a potential candidate for the treatment of hepatic fibrosis, based on its regulation of FXR/LXR axis-mediated inhibition of autophagy through crosstalk between hepatic cells and macrophage
Silibinin 📋✍ 34250649Silibinin alleviates silica-induced pulmonary fibrosis: Potential role in modulating inflammation and epithelial-mesenchymal transition
Allicin 📋✍⛔31953094Allicin Inhibits Proliferation and Promotes Apoptosis of Human Epidural Scar Fibroblasts
Beta-Carotene 📋✍⛔32686990β-carotene inhibits NF-κB and restrains diethylnitrosamine-induced hepatic inflammation in Wistar rats
Biochanin A 📋 38091641Biochanin A inhibits cardiac hypertrophy and fibrosis in vivo and in vitro
Butyrate 📋 ⛔37852118Butyrate alleviates renal fibrosis in CKD by regulating NLRP3-mediated pyroptosis via the STING/NF-κB/p65 pathway
Cannabidiol 📋✍⛔38711461Cannabidiol alleviates carbon tetrachloride-induced liver fibrosis in mice by regulating NF-κB and PPAR-α pathways
Catalpol 📋 36508052Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles
Cinnamaldehyde 📋 38143035Cinnamaldehyde has antifibrotic effects on rats with epidural fibrosis
Eicosapentaenoic Acid 📋✍⛔36206854Eicosapentaenoic Acid Ameliorates Cardiac Fibrosis and Tissue Inflammation in Spontaneously Hypertensive Rats
Fish Oil 📋✍⛔12049831Dietary fish oil protects against lung and liver inflammation and fibrosis in monocrotaline treated rats
Galangin 📋 33328989Galangin Attenuates Isoproterenol-Induced Inflammation and Fibrosis in the Cardiac Tissue of Albino Wistar Rats
Gardenia 📋 ⛔37355063A novel branched galacturonan from Gardenia jasminoides alleviates liver fibrosis linked to TLR4/NF-κB signaling
Ginkgolic Acid 📋 38387271Ginkgolic acid inhibits the expression of SAE1 and induces ferroptosis to exert an anti-hepatic fibrosis effect
Glabridin 📋 37714449Glabridin ameliorates intracellular events caused by palmitic acid and alcohol in mouse hepatocytes and fast food diet and alcohol -induced steatohepatitis and fibrosis in C57BL/6J mice model
Goji Berry 📋✍⛔37690228Microbial modifications with Lycium barbarum L. oligosaccharides decrease hepatic fibrosis and mitochondrial abnormalities in mice
Holy Basil 📋✍⛔37694023Assessment of Aloe Vera and Tulsi's Effectiveness in Treating Oral Submucous Fibrosis
Indian Gooseberry 📋 ⛔37313177Effects of one-year supplementation with Phyllanthus niruri on fibrosis score and metabolic markers in patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial
Isoliquiritigenin 📋 35489326Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice
Magnolol 📋 37282760Magnolol alleviates pulmonary fibrosis inchronic obstructive pulmonary disease by targeting transient receptor potential vanilloid 4-ankyrin repeat domain
Parthenolide 📋 36792295Parthenolide alleviates peritoneal fibrosis by inhibiting inflammation via the NF-κB/ TGF-β/Smad signaling axis
Peony 📋 ⛔37666859Exploring the role and mechanism of Astragalus membranaceus and radix paeoniae rubra in idiopathic pulmonary fibrosis through network pharmacology and experimental validation
Polydatin 📋✍ 37665061Polydatin alleviates bleomycin-induced pulmonary fibrosis and alters the gut microbiota in a mouse model
Pomegranate 📋 ⛔36938469A standardized pomegranate fruit extract ameliorates thioacetamide-induced liver fibrosis in rats via AGE-RAGE-ROS signaling
Pomegranate Peel extract 📋✍⛔32718261Combination of pomegranate extract and curcumin ameliorates thioacetamide-induced liver fibrosis in rats: Impact on TGF-β/Smad3 and NF-κB signaling pathways
Pomegranate Seed extract 📋 ⛔32751794Cold Press Pomegranate Seed Oil Attenuates Dietary-Obesity Induced Hepatic Steatosis and Fibrosis through Antioxidant and Mitochondrial Pathways in Obese Mice
Proanthocyanidins 📋 37615088Proanthocyanidin A2 attenuates the activation of hepatic stellate cells by activating the PPAR-γ signalling pathway
Retinoic Acid 📋 34211477Retinoic Acid: A New Old Friend of IL-17A in the Immune Pathogeny of Liver Fibrosis
Rhubarb 📋 ⛔36105187The progress and prospect of natural components in rhubarb ( Rheum ribes L.) in the treatment of renal fibrosis
Spermidine 📋 37380734Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis
St. Johns Wort 📋✍⛔31894670[Effects of hypericum perforatum extract on the immunogenic myocardial fibrosis in mice and its mechanism]
Thymoquinone 📋 ⛔38504479Thymoquinone protects thioacetamide-induced chronic liver injury by inhibiting TGF-β1/Smad3 axis in rats
Turmeric 📋✍⛔35982996Mechanistic Investigation of Curcuma Protection against Oral Submucous Fibrosis
Aloin 📋 38038700Aloin Attenuates Oxidative Stress, Inflammation, and CCl4-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling
Artemisinin 📋 38250467Artesunate Induces Ferroptosis in Hepatic Stellate Cells and Alleviates Liver Fibrosis via the ROCK1/ATF3 Axis
Aspirin 📋 ⛔37114173The hepatoprotective effect of aspirin on carbon tetrachloride‑induced hepatic fibrosis via inhibition of TGFβ‑1 pathway and pro‑inflammatory cytokines IL‑1β and COX‑2 in rats
Astragalin 📋 33916310Astragalin Inhibits Cigarette Smoke-Induced Pulmonary Thrombosis and Alveolar Inflammation and Disrupts PAR Activation and Oxidative Stress-Responsive MAPK-Signaling
Atractylodes 📋✍⛔37641404Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-β receptor 1 recycling by stabilizing vimentin
Beta-Sitosterol 📋✍⛔31373816Effects of β-Sitosterol From Corn Silk on TGF-β1-Induced Epithelial-Mesenchymal Transition in Lung Alveolar Epithelial Cells
Bitter Melon 📋✍⛔34239589Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis
Bromelain 📋✍⛔37269556Bromelain mitigates liver fibrosis via targeting hepatic stellate cells in vitro and in vivo
Caffeine 📋✍⛔35065262Caffeine mitigates experimental nonalcoholic steatohepatitis and the progression of thioacetamide-induced liver fibrosis by blocking the MAPK and TGF-β/Smad3 signaling pathways
Carnosol 📋 36552549Protective Effects of Carnosol on Renal Interstitial Fibrosis in a Murine Model of Unilateral Ureteral Obstruction
Chokeberry 📋✍⛔36344052Aronia melanocarpa polysaccharide ameliorates liver fibrosis through TGF-β1-mediated the activation of PI3K/AKT pathway and modulating gut microbiota
Choline 📋✍⛔32797252Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota
Chondroitin 📋✍⛔35163920Chondroitin Sulfate Protects the Liver in an Experimental Model of Extra-Hepatic Cholestasis Induced by Common Bile Duct Ligation
Chrysanthemum 📋✍⛔34563177Effect of supercritical carbon dioxide fluid extract from Chrysanthemum indicum Linné on bleomycin-induced pulmonary fibrosis
Cryptotanshinone 📋 37213406Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress
D-Mannose 📋✍⛔38293175Mannose Supplementation Curbs Liver Steatosis and Fibrosis in Murine MASH by Inhibiting Fructose Metabolism
Eucalyptus 📋✍⛔35834630Protective Effect of Eucalyptus globulus Extracts Against Bleomycin-Induced Pulmonary Fibrosis in Rats
Ginkgetin 📋 38217097Ginkgetin exhibits antifibrotic effects by inducing hepatic stellate cell apoptosis via STAT1 activation
Glutathione 📋✍⛔32856877The Protective Effect of Antioxidants in Areca Nut Extract-Induced Oral Carcinogenesis
Glycyrrhetinic Acid 📋 37586613Glycyrrhetinic acid mitigates radiation-induced pulmonary fibrosis via inhibiting the secretion of TGF-β1 by Treg cells
Green Tea 📋✍⛔35002452Hepatoprotective effects of methanolic extract of green tea against Thioacetamide-Induced liver injury in Sprague Dawley rats
Hydroxytyrosol 📋 38281774Hydroxytyrosol Alleviates Methotrexate-Induced Pulmonary Fibrosis in Rats: Involvement of TGF-β1, Tissue Factor, and VEGF
Hyperoside 📋 37923159Hyperoside attenuates carbon tetrachloride-induced hepatic fibrosis via the poly(ADP-ribose)polymerase-1-high mobility group protein 1 pathway
Isorhamnetin 📋 37598299Isorhamnetin Exerts Antifibrotic Effects by Attenuating Platelet-Derived Growth Factor-BB-induced HSC-T6 Cells Activation via Suppressing PI3K-AKT Signaling Pathway
L-Carnosine 📋✍⛔38348353Iron scavenging and suppression of collagen cross-linking underlie antifibrotic effects of carnosine in the heart with obesity
Licorice Root 📋✍⛔31072167The effects of methanolic extract of Glycyrrhiza glabra on the prevention and treatment of bleomycin-induced pulmonary fibrosis in rat: experimental study
Ligustilide 📋 36921687Levistolide A ameliorates fibrosis in chronic kidney disease via modulating multitarget actions in vitro and in vivo
Liquiritigenin 📋 38238857The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin
Liquiritin 📋 36483459Liquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway
Loquat 📋✍⛔29857545Anti-Apoptosis and Anti-Fibrosis Effects of Eriobotrya Japonica in Spontaneously Hypertensive Rat Hearts
Lychee 📋 ⛔33671028Protective Effect of Oligonol on Dimethylnitrosamine-Induced Liver Fibrosis in Rats via the JNK/NF-κB and PI3K/Akt/Nrf2 Signaling Pathways
Myrrh 📋✍⛔35983967Myrrhone inhibits the progression of hepatic fibrosis by regulating the abnormal activation of hepatic stellate cells
Neferine 📋 35347819Neferine attenuates doxorubicin-induced fibrosis and hypertrophy in H9c2 cells
Nobiletin 📋✍ 38044268Nobiletin Alleviated Epithelial-Mesenchymal Transition of Hepatocytes in Liver Fibrosis Based on Autophagy-Hippo/YAP Pathway
Ollive Leaf extract 📋✍⛔37667683Olea europaea L. Leaf Extract Alleviates Fibrosis Progression and Oxidative Stress Induced by Bleomycin on a Murine Model of Lung Fibrosis
Pine Bark 📋✍⛔34653662Anti-fibrotic effect of Pycnogenol® in a polyhexamethylene guanidine-treated mouse model
Piperlongumine 📋 37121453Piperlonguminine attenuates renal fibrosis by inhibiting TRPC6
Polyphenols 📋 38202710Research Progress Regarding the Effect and Mechanism of Dietary Polyphenols in Liver Fibrosis
PQQ 📋✍⛔38613355Pyrroloquinoline quinone ameliorates PM2.5-induced pulmonary fibrosis through targeting epithelial-mesenchymal transition
Rapamycin 📋✍ 38548510Beneficial Effect of Rapamycin on Liver Fibrosis in a Mouse Model (C57bl/6 Mouse)
Rehmannia 📋✍⛔37579922Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple ameliorates renal interstitial fibrosis in CKD rats by inhibiting the TGF-β1/MAPK signaling pathway
Rice 📋 ⛔36379906Resistant starch from black rice, Oryza sativa L. var. ameliorates renal inflammation, fibrosis and injury in insulin resistant rats
Safflower 📋✍⛔36686974The Carthamus tinctorius L. and Lepidium apetalum Willd. Drug Pair Inhibits EndMT through the TGF β 1/Snail Signaling Pathway in the Treatment of Myocardial Fibrosis
Sea Buckthorn 📋✍⛔30398061Active Components from Sea Buckthorn ( Hippophae rhamnoides L.) Regulate Hepatic Stellate Cell Activation and Liver Fibrogenesis
Skullcap 📋✍⛔38616754Network Pharmacology, Molecular Docking Analysis and Molecular Dynamics Simulation of Scutellaria baicalensis in the Treatment of Liver Fibrosis
Spirulina 📋✍⛔30669332Spirulina Liquid Extract Protects against Fibrosis Related to Non-Alcoholic Steatohepatitis and Increases Ursodeoxycholic Acid
Star Fuit 📋 ⛔31733577Effect of an aqueous extract of Averrhoa carambola L. on endothelial function in rats with ventricular remodelling
Syringic Acid 📋 35719043Syringic acid mitigates isoproterenol-induced cardiac hypertrophy and fibrosis by downregulating Ereg
Tangeretin 📋 37781713Tangeretin attenuates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition via the PI3K/Akt pathway
Telmisartan 📋 ⛔34942161Telmisartan relieves liver fibrosis and portal hypertension by improving vascular remodeling and sinusoidal dysfunction
Theaflavins 📋✍ 37549726Theaflavine inhibits hepatic stellate cell activation by modulating the PKA/LKB1/AMPK/GSK3β cascade and subsequently enhancing Nrf2 signaling
Tribulus Terrestris 📋✍⛔35789496Mechanisms exploration of Terrestrosin D on pulmonary fibrosis based on plasma metabolomics and network pharmacology
UDCA 📋✍⛔22301109Ursodeoxycholate modulates bile flow and bile salt pool independently from the cystic fibrosis transmembrane regulator (Cftr) in mice
Ursolic Acid 📋✍⛔36252479Ursolic acid alleviates Kupffer cells pyroptosis in liver fibrosis by the NOX2/NLRP3 inflammasome signaling pathway
Vitamin B2 📋✍⛔37331684Riboflavin ameliorates pathological cardiac hypertrophy and fibrosis through the activation of short-chain acyl-CoA dehydrogenase
Vitamin B8 📋✍⛔37194070Inositol possesses antifibrotic activity and mitigates pulmonary fibrosis
Vitamin B9 📋✍⛔33994505Low Dose of Folic Acid Can Ameliorate Hyperhomocysteinemia-Induced Cardiac Fibrosis and Diastolic Dysfunction in Spontaneously Hypertensive Rats
Vitamin K1 📋✍⛔28717059Pharmacological effects of a vitamin K 1 2,3-epoxide reductase (VKOR) inhibitor, 3-acetyl-5-methyltetronic acid, on cisplatin-induced fibrosis in rats
Withaferin A 📋 33029279Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner
Zingerone 📋 32377772Zingerone Ameliorates Oxidative Stress and Inflammation in Bleomycin-Induced Pulmonary Fibrosis: Modulation of the Expression of TGF-β1 and iNOS
Acacetin 📋 37348478Acacetin alleviates cardiac fibrosis via TGF-β1/Smad and AKT/mTOR signal pathways in spontaneous hypertensive rats
Acai Berry 📋✍⛔36460743Polyphenol-rich açaí seed extract exhibits reno-protective and anti-fibrotic activities in renal tubular cells and mice with kidney failure
Aloe-Emodin 📋 30215298Aloe-Emodin Ameliorates Renal Fibrosis Via Inhibiting PI3K/Akt/mTOR Signaling Pathway In Vivo and In Vitro
Apricot Kernels 📋✍⛔21736706Can apricot kernels fatty acids delay the atrophied hepatocytes from progression to fibrosis in dimethylnitrosamine (DMN)-induced liver injury in rats?
Arjuna 📋✍⛔28821620Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling
Balloon Flower 📋✍⛔38293977[Platycodin D improves pulmonary fibrosis in mice by down-regulating TRPC6 expression and reducing ROS production in lung fibroblasts]
Barberry 📋✍⛔27261610Protective effect of Berberis vulgaris fruit extract against Paraquat-induced pulmonary fibrosis in rats
Basil Essential Oil 📋✍⛔26213907Hepatocyte Growth Factor Mediates the Antifibrogenic Action of Ocimum bacilicum Essential Oil against CCl4-Induced Liver Fibrosis in Rats
BCAA 📋✍⛔32872742Anti-fibrotic effects of branched-chain amino acids on hepatic stellate cells
Bee Venom 📋✍⛔34031696Apamin inhibits renal fibrosis via suppressing TGF-β1 and STAT3 signaling in vivo and in vitro
Betulinic Acid 📋 35714879Betulinic acid prevents liver fibrosis by binding Lck and suppressing Lck in HSC activation and proliferation
Bilobalide 📋 36733844Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Bilobalide
Black Tea Polyphenols 📋 25927469Protective effect of theaflavin-enriched black tea extracts against dimethylnitrosamine-induced liver fibrosis in rats
Blackcurrant 📋✍⛔30569636Blackcurrant (Ribes nigrum) Prevents Obesity-Induced Nonalcoholic Steatohepatitis in Mice
Boswellic Acid 📋✍⛔30054990Acetyl-11-keto-β-boswellic acid ameliorates renal interstitial fibrosis via Klotho/TGF-β/Smad signalling pathway
Buckwheat 📋 ⛔37150497Tartary buckwheat flavonoids alleviates high-fat diet induced kidney fibrosis in mice by inhibiting MAPK and TGF-β1/Smad signaling pathway
Caffeic Acid 📋✍⛔33448051Inhibitory effect of caffeic acid on advanced glycation end product-induced renal fibrosis in vitro: A potential therapeutic target
Camellia 📋 ⛔32400797Camellia oil (Camellia oleifera Abel.) attenuates CCl 4-induced liver fibrosis via suppressing hepatocyte apoptosis in mice
CAPE 📋 34529223Role of inflammation and oxidative stress in tissue damage associated with cystic fibrosis: CAPE as a future therapeutic strategy
Captopril 📋 37983238Oral angiotensin-converting enzyme inhibitor captopril protects the heart from Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice
Cardamom 📋✍⛔28806968Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats
Cardamonin 📋 37646396Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis
Carotenoids 📋✍⛔17569601A Pilot Study on the Safety and Efficacy of a Novel Antioxidant Rich Formulation in Patients With Cystic Fibrosis
Catechins 📋 35917528(-)-Epicatechin Ameliorates Cardiac Fibrosis in a Female Rat Model of Pre-Heart Failure with Preserved Ejection Fraction
Chaga Mushrooms 📋✍⛔35601068Inonotsuoxide B suppresses hepatic stellate cell activation and proliferation via the PI3K/AKT and ERK1/2 pathway
Chamomile 📋✍⛔31143217Effect of Chamomile Hydroalcoholic Extract on Bleomycin-Induced Pulmonary Fibrosis in Rat
Chili Pepper 📋 ⛔35600864The Antifibrotic and the Anticarcinogenic Activity of Capsaicin in Hot Chili Pepper in Relation to Oral Submucous Fibrosis
Chitosan 📋✍⛔37749921Pharmacodynamic study of chitosan in combination with salvianolic acid B in the treatment of CC14 -induced liver fibrosis in mice
Chlorella 📋✍⛔33296068Therapeutic effects of Chlorella vulgaris on carbon tetrachloride induced liver fibrosis by targeting Hippo signaling pathway and AMPK/FOXO1 axis
Cinnamic Acid 📋 37581637Cinnamic acid mitigates methotrexate-induced lung fibrosis in rats: comparative study with pirfenidone
Citicoline 📋✍⛔23015343Prevention of epidural fibrosis in rats by local or systemic administration of citicoline
Citronella Essential Oil 📋✍⛔34065064Cymbopogon winterianus Essential Oil Attenuates Bleomycin-Induced Pulmonary Fibrosis in a Murine Model
Collagen 📋✍ 38140281Effects of Long-Term Administration of Bovine Bone Gelatin Peptides on Myocardial Hypertrophy in Spontaneously Hypertensive Rats
Coptis Chinensis 📋 ⛔23190573A comparative study on the hepatoprotective action of bear bile and Coptidis Rhizoma aqueous extract on experimental liver fibrosis in rats
Cordycepin 📋 38565039Cordycepin alleviates hepatic fibrosis in association with the inhibition of glutaminolysis to promote hepatic stellate cell senescence
Cornus 📋 37579922Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple ameliorates renal interstitial fibrosis in CKD rats by inhibiting the TGF-β1/MAPK signaling pathway
Coumaric acid 📋 36400112Attenuation of hepatic fibrosis by p-Coumaric acid via modulation of NLRP3 inflammasome activation in C57BL/6 mice
D-Limonene 📋✍⛔36496421D-Limonene inhibits the occurrence and progression of LUAD through suppressing lipid droplet accumulation induced by PM2.5 exposure in vivo and in vitro
Daidzein 📋✍⛔35151651Daidzein suppresses TGF-β1-induced cardiac fibroblast activation via the TGF-β1/SMAD2/3 signaling pathway
Dandelion 📋✍⛔20561925Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice
DHEA 📋✍⛔23143540Dehydroepiandrosterone has strong antifibrotic effects and is decreased in idiopathic pulmonary fibrosis
Diallyl Trisulfide 📋 35532220Diallyl trisulfide plays an antifibrotic role by inhibiting the expression of Bcl-2 in hepatic stellate cells
DIM 📋✍⛔36232707Hepatoprotective Effects of a Natural Flavanol 3,3'-Diindolylmethane against CCl4-Induced Chronic Liver Injury in Mice and TGFβ1-Induced EMT in Mouse Hepatocytes via Activation of Nrf2 Cascade
Dioscin 📋 36960871Mechanism of dioscin ameliorating renal fibrosis through NF‑κB signaling pathway‑mediated inflammatory response
Diosgenin 📋 32924642Diosgenin inhibits TGF-β1/Smad signaling and regulates epithelial mesenchymal transition in experimental pulmonary fibrosis
Echinacoside 📋 38366962Echinacoside Exerts Antihepatic Fibrosis Effects in High-Fat Mice Model by Modulating the ACVR2A-Smad Pathway
Eleuthero 📋✍⛔37467688Syringin alleviates hepatic fibrosis by enhancing autophagic flux and attenuating ER stress-TRIB3/SMAD3 in diabetic mice
Essential Fatty Acids 📋✍ 36364928Essential Fatty Acid Deficiency in Cystic Fibrosis Disease Progression: Role of Genotype and Sex
Essential Oils 📋 ⛔35792297Natural essential oils efficacious in internal organs fibrosis treatment: mechanisms of action and application perspectives
Eucalyptol 📋 35964659Eucalyptol prevents bleomycin-induced pulmonary fibrosis and M2 macrophage polarization
Eucalyptus Essential Oil 📋 ⛔35834630Protective Effect of Eucalyptus globulus Extracts Against Bleomycin-Induced Pulmonary Fibrosis in Rats
Fenugreek 📋✍⛔28883697Protective Effects of Foeniculum vulgare Root Bark Extract Against Carbon Tetrachloride-Induced Hepatic Fibrosis in Mice
Fish 📋 ⛔9233748Dietary fish oil and fish and borage oil suppress intrapulmonary proinflammatory eicosanoid biosynthesis and attenuate pulmonary neutrophil accumulation in endotoxic rats
Flavonoids 📋 ⛔37664726Natural plant resource flavonoids as potential therapeutic drugs for pulmonary fibrosis
Flaxseed Oil 📋✍⛔35485674Clinical Assessment of Efficacy of Omega 3 in Oral Submucous Fibrosis Patients - A Randomized Controlled Trial
Fo-Ti Root 📋✍⛔362672832,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside ameliorates bleomycin-induced pulmonary fibrosis via regulating pro-fibrotic signaling pathways
Folate 📋✍⛔37630806Folate Deficiency Enhanced Inflammation and Exacerbated Renal Fibrosis in High-Fat High-Fructose Diet-Fed Mice
Food 📋 35215502Nutrition in Cystic Fibrosis-Some Notes on the Fat Recommendations
Formononetin 📋 38070245Formononetin ameliorates isoproterenol induced cardiac fibrosis through improving mitochondrial dysfunction
Forskolin 📋✍⛔33576062Concomitant Inhibition of Hedgehog Signalling and Activation of Retinoid Receptors abolishes Bleomycin-induced Lung fibrosis
Frankincense 📋✍⛔23111960Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation
Gamma-Linolenic Acid 📋✍⛔20045240Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis
Geraniol 📋 33274899Hepatoprotective Impact of Geraniol Against CCl 4-Induced Liver Fibrosis in Rats
Ginger extract 📋✍⛔21689445Zingiber officinale acts as a nutraceutical agent against liver fibrosis
Ginkgolides 📋 29710472Diterpene ginkgolides meglumine injection protects against paraquat-induced lung injury and pulmonary fibrosis in rats
Green Tea Polyphenols 📋✍⛔17235729Green Tea Extract Inhibits Paraquat-Induced Pulmonary Fibrosis by Suppression of Oxidative Stress and Endothelin-L Expression
Guava 📋 ⛔34961420Psidium guajava Flavonoids Prevent NLRP3 Inflammasome Activation and Alleviate the Pancreatic Fibrosis in a Chronic Pancreatitis Mouse Model
Guggulsterone 📋 35123992Z-Guggulsterone alleviates renal fibrosis by mitigating G2/M cycle arrest through Klotho/p53 signaling
Haritaki 📋✍⛔27021876Chebulic acid prevents hepatic fibrosis induced by advanced glycation end-products in LX-2 cell by modulating Nrf2 translocation via ERK pathway
Hawthorn 📋✍⛔33255507Hawthorn Herbal Preparation from Crataegus oxyacantha Attenuates In Vivo Carbon Tetrachloride -Induced Hepatic Fibrosis via Modulating Oxidative Stress and Inflammation
Honey 📋✍⛔32852889Manuka honey versus saline sinus irrigation in the treatment of cystic fibrosis-associated chronic rhinosinusitis: A randomized pilot trial
Icaritin 📋 34153405PPARγ mediates the anti-pulmonary fibrosis effect of icaritin
Kiwifruit 📋✍⛔36328432[Unsaturated fatty acid of Actinidia chinesis planch seed oil protects against pulmonary fibrosis by inhibiting collagen synthesis via down-regulating connective tissue growth factor (CTGF) expression in rats]
L-Alanine 📋✍⛔35698613Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis
L-Glutamine 📋✍⛔34634441Glutamine restores mitochondrial respiration in bleomycin-injured epithelial cells
L-Theanine 📋✍⛔25852135l-Theanine prevents carbon tetrachloride-induced liver fibrosis via inhibition of nuclear factor κB and down-regulation of transforming growth factor β and connective tissue growth factor
Lecithin 📋✍⛔33009655A dry powder inhalable formulation of salvianolic acids for the treatment of pulmonary fibrosis: safety, lung deposition, and pharmacokinetic study
Limonin 📋 35533902Limonin relieves TGF-β-induced hepatocyte EMT and hepatic stellate cell activation in vitro and CCl 4-induced liver fibrosis in mice via upregulating Smad7 and subsequent suppression of TGF-β/Smad cascade
Lingonberry 📋 ⛔34735147Lingonberry Anthocyanins Inhibit Hepatic Stellate Cell Activation and Liver Fibrosis via TGFβ/Smad/ERK Signaling Pathway
Linoleic Acid 📋✍⛔35958259Dietary linoleic acid and the ratio of unsaturated to saturated fatty acids are inversely associated with significant liver fibrosis risk: A nationwide survey
Lotus 📋 ⛔34724865Protective effects of lotus plumule ethanol extracts on bleomycin-induced pulmonary fibrosis in mice
Medicinal Plants 📋 27081574Natural Compounds as Therapeutic Agents in the Treatment Cystic Fibrosis
Morin 📋 34843935Morin inhibits the transformation of fibroblasts towards myofibroblasts through regulating "PPAR-γ-glutaminolysis-DEPTOR" pathway in pulmonary fibrosis
Moringa Oleifera 📋✍⛔29214184Protective Effects of Moringa oleifera on HBV Genotypes C and H Transiently Transfected Huh7 Cells
Mulberry 📋 ⛔37324833Mulberroside A ameliorates CCl4-induced liver fibrosis in mice via inhibiting pro-inflammatory response
Mushrooms 📋 ⛔38154526Ganoderma lucidum ethanol extracts ameliorate hepatic fibrosis and promote the communication between metabolites and gut microbiota g_Ruminococcus through the NF-κB and TGF-β1/Smads pathways
Myricetin 📋 ⛔32535102Myricetin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice by Inhibiting TGF-β Signaling via Targeting HSP90β
Myrtle 📋✍⛔27664884Effects of Myrtus communis extract treatment in bile duct ligated rats
NAD 📋 33440677Nicotinamide Attenuates the Progression of Renal Failure in a Mouse Model of Adenine-Induced Chronic Kidney Disease
Nicotinamide 📋✍⛔34179114Nicotinamide Supplementation Attenuates Renal Interstitial Fibrosis via Boosting the Activity of Sirtuins
Nimbolide 📋 31377591Therapeutic effects of Nimbolide, an autophagy regulator, in ameliorating pulmonary fibrosis through attenuation of TGF-β1 driven epithelial-to-mesenchymal transition
Nootkatone 📋 34480883Nootkatone confers antifibrotic effect by regulating the TGF-β/Smad signaling pathway in mouse model of unilateral ureteral obstruction
Oak Bark 📋✍⛔22105311Cardioprotective and hepatoprotective effects of ellagitannins from European oak bark (Quercus petraea L.) extract in rats
Oats 📋 ⛔34965258The involvement of TGF-β1 /FAK/α-SMA pathway in the antifibrotic impact of rice bran oil on thioacetamide-induced liver fibrosis in rats
Oleuropein 📋 28300585Exploiting oleuropein for inhibiting collagen fibril formation
Olive Oil 📋✍⛔38051691The effectiveness of organic vegetable oils with high biocompatibility in preventing epidural fibrosis: An experimental study
Olive Polyphenols 📋 34671630The Extra Virgin Olive Oil Polyphenol Oleocanthal Exerts Antifibrotic Effects in the Liver
Onion 📋✍⛔35377371Protective role of Siberian onions against toxin-induced liver dysfunction: an insight into health-promoting effects
Oregano Essential Oil 📋✍⛔27534136Essential Oil from Origanum vulgare Completely Inhibits the Growth of Multidrug-Resistant Cystic Fibrosis Pathogens
Paeonol 📋 34696937Paeonol inhibits profibrotic signaling and HOTAIR expression in fibrotic buccal mucosal fibroblasts
Patchouli 📋✍⛔37177974Patchouli alcohol against renal fibrosis of spontaneously hypertensive rats via Ras/Raf-1/ERK1/2 signalling pathway
Peach 📋 ⛔36105786Peach Kernel Extracts Inhibit Lipopolysaccharide-Induced Activation of HSC-T6 Hepatic Stellate Cells
Peas 📋 ⛔34630950Nutrition profile and potency of RGD motif in protein hydrolysate of green peas as an antifibrosis in chronic kidney disease
Peppermint Essential Oil 📋✍⛔29849890Antifibrogenic Influence of Mentha piperita L. Essential Oil against CCl 4-Induced Liver Fibrosis in Rats
Phloretin 📋 37533177Phloretin Ameliorates Succinate-Induced Liver Fibrosis by Regulating Hepatic Stellate Cells
Phosphatidylcholine 📋✍⛔32797252Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota
Phytochemicals 📋 33548106Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals
Phytoestrogens 📋 ⛔34684599Dietary Phytoestrogens Ameliorate Hydrochloric Acid-Induced Chronic Lung Injury and Pulmonary Fibrosis in Mice
Pistachio 📋✍⛔31599067Mastiha (Pistacia lentiscus) Improves Gut Microbiota Diversity, Hepatic Steatosis, and Disease Activity in a Biopsy-Confirmed Mouse Model of Advanced Non-Alcoholic Steatohepatitis and Fibrosis
Poria Mushrooms 📋✍ 31452866Combined melatonin and poricoic acid A inhibits renal fibrosis through modulating the interaction of Smad3 and β-catenin pathway in AKI-to-CKD continuum
Procyanidins 📋 ⛔26308756Hepatoprotective Effects of Grape Seed Procyanidin B2 in Rats With Carbon Tetrachloride-induced Hepatic Fibrosis
PUFA 📋 34578843PUFA Supplementation and Heart Failure: Effects on Fibrosis and Cardiac Remodeling
Pyridoxal-5-Phosphate 📋✍⛔37946524Upregulation of ATP-Sensitive Potassium Channels as the Potential Mechanism of Cardioprotection and Vasorelaxation Under the Action of Pyridoxal-5-Phosphate in Old Rats
Rosavin 📋 ⛔36077546Rosavin Ameliorates Hepatic Inflammation and Fibrosis in the NASH Rat Model via Targeting Hepatic Cell Death
Rose 📋 37797686Evaluation of the flavonol-rich fraction of Rosa damascena in an animal model of liver fibrosis by targeting the expression of fibrotic cytokines, antioxidant/oxidant ratio and collagen cross-linking
Roselle 📋✍⛔36562602The Nephroprotective Effects of Hibiscus sabdariffa Leaf and Ellagic Acid in Vitro and in Vivo Models of Hyperuricemic Nephropathy
Rosemary 📋✍⛔32781430Inhibition of p66Shc Oxidative Signaling via CA-Induced Upregulation of miR-203a-3p Alleviates Liver Fibrosis Progression
Royal Jelly 📋✍⛔37236025Royal jelly mediates fibrotic signaling, collagen cross-linking and cell proliferation in cardiac fibroblasts
Saffron 📋✍⛔38055395Saffron reduces the liver fibrosis in mice by inhibiting the JAK/STAT3 pathway
Sage 📋✍⛔31608667Salvia officinalis attenuates bleomycin-induced oxidative stress and lung fibrosis in rats
Scutellarin 📋 33188176Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial-mesenchymal transition and inflammation
Sea Cucumber 📋 38018265Inhibition of bleomycin-induced pulmonary fibrosis in SD rats by the sea cucumber peptides
Sesame Oil 📋 ⛔34824517Novel Treatment Approach of Oral Submucous Fibrosis in a 6-year-old Girl: A Case Report
Shogaol 📋 354850776-Shogaol alleviates CCl4-induced liver fibrosis by attenuating inflammatory response in mice through the NF-κB pathway
Sirtuin Activators 📋 38294557SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging
Sugarcane 📋 ⛔29322133Anti-fibrotic activity of polyphenol-enriched sugarcane extract in rats via inhibition of p38 and JNK phosphorylation
Tetrahydrocurcumin 📋✍ 29468071Dietary Tetrahydrocurcumin Reduces Renal Fibrosis and Cardiac Hypertrophy in 5/6 Nephrectomized Rats
Theabrownins 📋 36742397Theabrownin ameliorates liver inflammation, oxidative stress, and fibrosis in MCD diet-fed C57BL/6J mice
Thyme 📋✍⛔34278915Thymus Vulgaris Inhibit Lung Fibrosis Progression and Oxidative Stress Induced by Bleomycin in Wistar Rats
Thymol 📋✍⛔36549352Thymol protects against bleomycin-induced pulmonary fibrosis via abrogation of oxidative stress, inflammation, and modulation of miR-29a/TGF-β and PI3K/Akt signaling in mice
Tongkat Ali 📋✍⛔37433989Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via regulating serum uric acid level and relieving inflammatory reaction
Trehalose 📋 ⛔32868830Trehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells
Vitamin B12 📋✍⛔19277125Preliminary evidence for cell membrane amelioration in children with cystic fibrosis by 5-MTHF and vitamin B12 supplementation: a single arm trial
Vitamin B3 📋✍⛔15182488[Effect of Niacin on Nitric Oxide Synthase Expression in Rat Lung Exposed to Silica]
Walnut 📋 ⛔32276127Juglanin alleviates bleomycin-induced lung injury by suppressing inflammation and fibrosis via targeting sting signaling
White Mushrooms 📋 ⛔34441565White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice
White Tea 📋 ⛔38628196Investigation of the effects of white tea on liver fibrosis: An experimental animal model
Wine 📋 ⛔22105311Cardioprotective and hepatoprotective effects of ellagitannins from European oak bark (Quercus petraea L.) extract in rats
Withanolides 📋 38301983Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects
Wogonin 📋✍⛔31377590Wogonin Attenuates Liver Fibrosis via Regulating Hepatic Stellate Cell Activation and Apoptosis
Yohimbine 📋✍ 37952411Yohimbine ameliorates liver inflammation and fibrosis by regulating oxidative stress and Wnt/β-catenin pathway